Selected Publications
2024
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Alexandre C, Miracca G, Holanda VD, Sharma A, Kourbanova K, Ferreira A, Bicca MA, Zeng X, Nassar VA, Lee S, Kaur S, Sarma SV, Sacré P, Scammell TE, Woolf CJ, Latremoliere A. Nociceptor spontaneous activity is responsible for fragmenting non-rapid eye movement sleep in mouse models of neuropathic pain. Sci Transl Med. 2024 Apr 17;16(743):eadg3036. doi: 10.1126/scitranslmed.adg3036. Epub 2024 Apr 17. PMID: 38630850.
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Jeon SM, Pradeep A, Chang D, McDonough L, Chen Y, Latremoliere A, Crawford LK, Caterina MJ. Skin Reinnervation by Collateral Sprouting Following Spared Nerve Injury in Mice. J Neurosci. 2024 Apr 10;44(15):e1494232024. doi: 10.1523/JNEUROSCI.1494-23.2024. PMID: 38471780; PMCID: PMC11007315.
2023
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Cronin SJF, Andrews NA, Latremoliere A. Peripheralized sepiapterin reductase inhibition as a safe analgesic therapy. Front Pharmacol. 2023 May 12;14:1173599. doi: 10.3389/fphar.2023.1173599. PMID: 37251335; PMCID: PMC10213231.
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Sprague JM, Yekkirala AS, Singh B, Tochitsky I, Stephens M, Viramontes O, Ivanis J, Biscola NP, Havton LA, Woolf CJ, Latremoliere A. Bortezomib-induced neuropathy is in part mediated by the sensitization of TRPV1 channels. Commun Biol. 2023 Dec 5;6(1):1228. doi: 10.1038/s42003-023-05624-1. PMID: 38052846; PMCID: PMC10698173.
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Singer ML, Shin MK, Kim LJ, Freire C, Aung O, Pho H, East JA, Sgambati FP, Latremoliere A, Pham LV, Polotsky VY. The efficacy of intranasal leptin for opioid-induced respiratory depression depends on sex and obesity state. Front Physiol. 2023 Dec 13;14:1320151. doi: 10.3389/fphys.2023.1320151. PMID: 38162827; PMCID: PMC10756673.
2022
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Kourbanova K, Alexandre C and Latremoliere A (2022) Effect of sleep loss on pain—New conceptual and mechanistic avenues. Front. Neurosci. 16:1009902. doi: 10.3389/fnins.2022.100990
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Kim, L. J., Alexandre, C., Pho, H., Latremoliere, A., Polotsky, V. Y., & Pham, L. V. (2022). Diet-induced obesity leads to sleep fragmentation independently of the severity of sleep-disordered breathing. Journal of Applied Physiology, 133(6), 1284–1294. https://doi.org/10.1152/japplphysiol.00386.2022
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Edwards, R. R., Schreiber, K. L., Dworkin, R. H., Turk, D. C., Baron, R., Freeman, R., Jensen, T. S., Latremoliere, A., Markman, J. D., Rice, A. S., Rowbotham, M., Staud, R., Tate, S., Woolf, C. J., Andrews, N. A., Carr, D. B., Colloca, L., Cosma-Roman, D., Cowan, P., . . . Wesselmann, U. (2022b). Optimizing and Accelerating the Development of Precision Pain Treatments for Chronic Pain: IMMPACT Review and Recommendations. The Journal of Pain. https://doi.org/10.1016/j.jpain.2022.08.010
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Cronin, S. J. F., Rao, S., Tejada, M. A., Turnes, B. L., Licht-Mayer, S., Omura, T., Brenneis, C., Jacobs, E., Barrett, L., Latremoliere, A., Andrews, N., Channon, K. M., Latini, A., Arvanites, A. C., Davidow, L. S., Costigan, M., Rubin, L. L., Penninger, J. M., & Woolf, C. J. (2022). Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer. Science Translational Medicine, 14(660). https://doi.org/10.1126/scitranslmed.abj1531
2021
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Jha, M. K., Passero, J. V., Rawat, A., Ament, X. H., Yang, F., Vidensky, S., Collins, S. L., Horton, M. R., Hoke, A., Rutter, G. A., Latremoliere, A., Rothstein, J. D., & Morrison, B. M. (2021). Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in mice. Journal of Clinical Investigation, 131(21). PMID: 34491913.
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Lee, E., Wong, A. L., Pinni, S., von Guionneau, N., Harris, T. G., Kothari, R., Lan, M., Enzmann, B., Qiu, C., Zhou, A., Shores, J., Latremoliere, A., Höke, A., Mao, H. Q., & Tuffaha, S. (2021). Improving Nerve Coaptation Outcomes in Targeted Muscle Reinnervation: A Novel Bioengineered Device. Plastic and Reconstructive Surgery - Global Open, 9(10S), 99–100. https://doi.org/10.1097/01.gox.0000799608.37883.a2
2020
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Fujita, M., Scheffer, D. D. L., Turnes, B. L., Cronin, S. J. F., Latrémolière, A., Costigan, M., Woolf, C. J., Latini, A., & Andrews, N. A. (2019). Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice. Arthritis & Rheumatology, 72(1), 57–66. PMID: 31350812.
2019
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Davies, A. J., Kim, H. W., Gonzalez-Cano, R., Choi, J., Back, S. K., Roh, S. E., Johnson, E., Gabriac, M., Kim, M. S., Lee, J., Lee, J. E., Kim, Y. S., Bae, Y. C., Kim, S. J., Lee, K. M., Na, H. S., Riva, P., Latremoliere, A., Rinaldi, S., . . . Oh, S. B. (2019). Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury. Cell, 176(4), 716–728.e18. PMID: 30712871.
2018
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Alexandre, C., Latremoliere, A., & Finan, P. H. (2020). Effect of Sleep Loss on Pain. The Oxford Handbook of the Neurobiology of Pain, 556–608. https://doi.org/10.1093/oxfordhb/9780190860509.013.31.
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Cobos, E. J., Nickerson, C. A., Gao, F., Chandran, V., Bravo-Caparrós, I., González-Cano, R., Riva, P., Andrews, N. A., Latremoliere, A., Seehus, C. R., Perazzoli, G., Nieto, F. R., Joller, N., Painter, M. W., Ma, C. H. E., Omura, T., Chesler, E. J., Geschwind, D. H., Coppola, G., . . . Costigan, M. (2018). Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling. Cell Reports, 22(5), 1301–1312. PMID: 29386116.
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Cronin, S.J.F., Seehus, C., Weidinger, A. et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature 563, 564–568 (2018). PMID: 30405245.
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Inquimbert, P., Moll, M., Latremoliere, A., Tong, C. K., Whang, J., Sheehan, G. F., Smith, B. M., Korb, E., Athié, M. C., Babaniyi, O., Ghasemlou, N., Yanagawa, Y., Allis, C. D., Hof, P. R., & Scholz, J. (2018). NMDA Receptor Activation Underlies the Loss of Spinal Dorsal Horn Neurons and the Transition to Persistent Pain after Peripheral Nerve Injury. Cell Reports, 23(9), 2678–2689. PMID: 29847798.
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Latremoliere, A., Costigan, M. Combining Human and Rodent Genetics to Identify New Analgesics. Neurosci. Bull. 34, 143–155 (2018). PMID: 28667479.
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Liu Y*, Latremoliere A*, Li X*, Zhang Z*, Chen M, Wang X, Fang C, Zhu J, Alexandre C, Gao Z, Chen B, Ding X, Zhou JY, Zhang Y, Chen C, Wang KH, Woolf CJ, He Z. (2018) Touch and tactile neuropathic pain sensitivity are set by corticospinal projections. Nature. 2018 PMID: 30209395. * indicates co-author
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Latremoliere A*, Cheng L*, DeLisle M, Wu C, Chew S, Hutchinson EB, Sheridan A, Alexandre C, Latremoliere F, Sheu SH, Golidy S, Omura T, Huebner EA, Fan Y, Whitman MC, Nguyen E, Hermawan C, Pierpaoli C, Tischfield MA, Woolf CJ, Engle EC. (2018) Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration. Cell Rep. PMID: 30110642. * indicates co-author
2017
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Banno, T., Omura, T., Masaki, N., Arima, H., Xu, D., Okamoto, A., Costigan, M., Latremoliere, A., Matsuyama, Y., & Setou, M. (2017). Arachidonic acid containing phosphatidylcholine increases due to microglial activation in ipsilateral spinal dorsal horn following spared sciatic nerve injury. PLOS ONE, 12(5), e0177595. PMID: 28542572.
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Browne LE, Latremoliere A*, Lehnert BP, Grantham A, Ward C, Alexandre C, Costigan M, Michoud F, Roberson DP, Ginty DD, Woolf CJ. (2017) Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses. Cell Rep. PMID: 28683326
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Alexandre C*, Latremoliere A*, Ferreira A, Miracca G, Yamamoto M, Scammell TE, Woolf CJ. (2017) Decreased alertness due to sleep loss increases pain sensitivity in mice. Nat Med. PMID: 28481358. * indicates co-author
2016
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Andrews NA*, Latremoliere A*, Basbaum AI, Mogil JS, Porreca F, Rice AS, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, Iyengar S, Jensen MP, Kennedy JD, Lee N, Levine J, Lidster K, Machin I, McDermott MP, McMahon SB, Price TJ, Ross SE, Scherrer G, Seal RP, Sena ES, Silva E, Stone L, Svensson CI, Turk DC, Whiteside G. (2016) Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations. Pain. PMID: 26683237. * indicates co-author
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Kahle, K. T., Schmouth, J. F., Lavastre, V., Latremoliere, A., Zhang, J., Andrews, N., Omura, T., Laganière, J., Rochefort, D., Hince, P., Castonguay, G., Gaudet, R., Mapplebeck, J. C., Sotocinal, S. G., Duan, J., Ward, C., Khanna, A. R., Mogil, J. S., Dion, P. A., Woolf, C. J., … Rouleau, G. A. (2016). Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. Science signaling, 9(421), ra32. PMID: 27025876.
2015
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Belin, S., Nawabi, H., Wang, C., Tang, S., Latremoliere, A., Warren, P., Schorle, H., Uncu, C., Woolf, C. J., He, Z., & Steen, J. A. (2015). Injury-Induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics. Neuron, 86(4), 1000–1014. PMID: 25937169.
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Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M, Miracca G, Babaniyi O, Remor AP, Duong K, Riva P, Barrett LB, Ferreirós N, Naylor A, Penninger JM, Tegeder I, Zhong J, Blagg J, Channon KM, Johnsson K, Costigan M, Woolf CJ. (2015) Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron. PMID: 26087165.
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Nawabi, H., Belin, S., Cartoni, R., Williams, P., Wang, C., Latremolière, A., Wang, X., Zhu, J., Taub, D., Fu, X., Yu, B., Gu, X., Woolf, C., Liu, J., Gabel, C., Steen, J., & He, Z. (2015). Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Neuron, 88(4), 704–719. PMID: 26526391.
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Omura, T., Omura, K., Tedeschi, A., Riva, P., Painter, M., Rojas, L., Martin, J., Lisi, V., Huebner, E., Latremoliere, A., Yin, Y., Barrett, L. B., Singh, B., Lee, S., Crisman, T., Gao, F., Li, S., Kapur, K., Geschwind, D., . . . Woolf, C. (2015). Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron, 86(5), 1215–1227. PMID: 26004914.
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Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R. (2015) The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med. PMID: 25915831
2014
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Painter, M., Brosius Lutz, A., Cheng, Y. C., Latremoliere, A., Duong, K., Miller, C., Posada, S., Cobos, E., Zhang, A., Wagers, A., Havton, L., Barres, B., Omura, T., & Woolf, C. (2014). Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration. Neuron, 83(2), 331–343. PMID: 25033179.
2012
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Costigan, M., Latremoliere, A., & Woolf, C. J. (2012). Analgesia by inhibiting tetrahydrobiopterin synthesis. Current Opinion in Pharmacology, 12(1), 92–99. PMID: 22178186.
2011
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Kayserl, V., Latrémolièrel, A., Hamonl, M., & Bourgoinl, S. (2011). N-methyl-d-aspartate receptor-mediated modulations of the anti-allodynic effects of 5-HT1B/1D receptor stimulation in a rat model of trigeminal neuropathic pain. European Journal of Pain, 15(5), 451–458. PMID: 20965753.
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Latremoliere, A., & Costigan, M. (2011). GCH1, BH4 and pain. Current pharmaceutical biotechnology, 12(10), 1728–1741. PMID: 21466440.
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Ma, C. H. E., Omura, T., Cobos, E. J., Latrémolière, A., Ghasemlou, N., Brenner, G. J., van Veen, E., Barrett, L., Sawada, T., Gao, F., Coppola, G., Gertler, F., Costigan, M., Geschwind, D., & Woolf, C. J. (2011). Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice. Journal of Clinical Investigation, 121(11), 4332–4347. PMID: 21965333.
2010
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Kayser, V., Viguier, F., Ioannidi, M., Bernard, J. F., Latrémolière, A., Michot, B., Vela, J. M., Buschmann, H., Hamon, M., & Bourgoin, S. (2010). Differential anti-neuropathic pain effects of tetrodotoxin in sciatic nerve- versus infraorbital nerve-ligated rats – Behavioral, pharmacological and immunohistochemical investigations. Neuropharmacology, 58(2), 474–487. PMID: 19747496.
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2009
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Costigan M*, Moss A*, Latremoliere A*, Johnston C, Verma-Gandhu M, Herbert TA, Barrett L, Brenner GJ, Vardeh D, Woolf CJ, Fitzgerald M. (2009) T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity. J Neurosci. PMID: 19923276. * indicates co-author
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Latremoliere A, Woolf CJ. (2009) Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. PMID: 19712899
2008
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Latremoliere A, Mauborgne A, Masson J, Bourgoin S, Kayser V, Hamon M, Pohl M. (2008) Differential implication of proinflammatory cytokine interleukin-6 in the development of cephalic versus extracephalic neuropathic pain in rats. J Neurosci. PMID: 18716207.
2007
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Doucet, E., Latrémolière, A., Darmon, M., Hamon, M., & Emerit, M. B. (2007). Immunolabelling of the 5-HT 3B receptor subunit in the central and peripheral nervous systems in rodents. The European journal of neuroscience, 26(2), 355–366. PMID: 17650111.
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Meunier, A., Latrémolière, A., Dominguez, E., Mauborgne, A., Philippe, S., Hamon, M., Mallet, J., Benoliel, J. J., & Pohl, M. (2007). Lentiviral-mediated Targeted NF-κB Blockade in Dorsal Spinal Cord Glia Attenuates Sciatic Nerve Injury–induced Neuropathic Pain in the Rat. Molecular Therapy, 15(4), 687–697. PMID: 17299402.
2005
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​​​Meunier A*, Latremoliere A*, Mauborgne A, Bourgoin S, Kayser V, Cesselin F, Hamon M, Pohl M. (2005) Attenuation of pain-related behavior in a rat model of trigeminal neuropathic pain by viral-driven enkephalin overproduction in trigeminal ganglion neurons. Mol Ther. PMID: 15771963. * indicates co-author